Significance Of Fish Oil In Human Health

Ritika Srivastava, Vishal K. Singh, Farha Naaz and Ramendra K. Singh, Bioorganic Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad- 211002

2018-02-26 03:01:08



In recent times, seafood is gaining more focus on account of its richness in omega-3 fatty acids. Numerous investigations carried out revealed the health benefits of omega-3 fatty acids as a nutritional supplement against various life threatening diseases like cardiovascular diseases, cancers, skin diseases and many inflammatory diseases etc. They also play a significant role for the proper growth and development of the foetus. National and International health authorities have set up recommendations of daily fish oil intake due to the immense health potential it carries and it is necessary to create an awareness in the society on its importance, as the modern world has become a hub of various lifestyle diseases.

Life has become fast and convenient on account of the latest developments in technology but at the same time it has welcomed various health hazards also. Life style diseases are mainly associated with poor eating habits like the consumption of junk and processed foods rich in saturated fat, dietary deficiencies, over consumption of certain foods etc. Other reasons causing health risks include lack of physical activity, work stress, disturbed biological cycle and other factors which affect human beings of all generation. In this context it is of paramount importance to choose appropriate food which provides healthy balanced nutrition. Fish is considered as a cheap source of many essential nutrients especially fat and protein and hence is of value in human diet. It is highly recommended in the human diet due to its richness in two main fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These two fatty acids are polyunsaturated fatty acids (PUFA) and are classified as omega-3 fatty acids. The main sources of these omega-3 PUFA rich oils are the meat of fatty fish such as sardine, herring, mackerel, menhaden, salmon, the liver of cod and the blubber of marine mammals such as seals and whales.

Fish lipids/oil consists of triglycerides, phospholipids, fatty acids, wax esters, sterols and other minor compounds like glyceryl esters, glycolipids, hydrocarbons like squalene, sulpholipids etc. The fatty acid compositions of fish lipids are more complex constituting mainly monounsaturated fatty acids (MUFA) along with polyunsaturated fatty acids (PUFA) and some saturated fatty acids in different proportions. PUFAs are mainly contributed by omega-6 and omega-3 fatty acids with former being high in fresh water fishes and the latter being the major contributors in marine fishes. The omega-3 fatty acids which are important in human nutrition are α-linolenic acid (ALA), eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA). The oil of some species of sharks especially deep sea sharks have high squalene content of about 90% and it has many pharmaceutical as well as cosmetic applications. Central Institute of Fisheries technology (ICAR-CIFT) has developed methods of extraction, isolation and purification of squalene and obtained a yield of about 80% pure squalene from centrophorus sp. ICAR-CIFT has also developed the technology for extraction of poly unsaturated fatty acids (PUFA) from fish oil, thus making an important contribution towards nutritional security.

Utility of Fish Oil for Health: Omega-3 fatty acids an important constituent of fish oil, are dietary fibers having an array of health benefits. They are essential for various metabolic processes, from structural component to the cell membrane, essential for foetal development and are found abundant in brain and retina. Recent investigations conducted on omega-3 fatty acids has gained more recognition to seafood on account of the health benefit they provide and this is regarded to be one of the most promising development in human nutrition. EPA and DHA are precursors for several metabolites which are potential mediators beneficial for the prevention and treatment of numerous diseases. Studies revealed the role of long chain omega-3 PUFAs in the treatment of cardiovascular diseases, hypertension, diabetes, arthritis, depression, and migraines, skin diseases like psoriasis, eczema and other inflammatory and autoimmune disorders as well as cancer. Significance of fish oil in human life is elaborated as follows:

Omega-3 fatty acids and cardiovascular disease: Cardiovascular disease (CVD) refers to the health disorder related with heart and related circulatory system. It is an outstanding disease in the modern world and is mainly associated with the eating of fat rich in saturated components. Chronic inflammation is thought to be the cause of many chronic diseases; including CVDs. CVDs are associated with the narrowing of large arteries with atheromatous plaques, or the total occlusion of coronary arteries (thrombosis) caused by atheromatous blockages leading to myocardial tissue necrosis. Both conditions reduce the heart's ability to pump blood and can result in either chronic or sudden heart failure. It is becoming apparent that regular consumption of fatty fish or fish oil lowers the rate of incidence and death from cardiovascular disease.  The omega-3 fatty acids decrease the platelet aggregation leading to a modest prolongation of bleeding time. Apart from these benefits, omega-3 fatty acid intake results in changes in blood lipid levels. It was observed to reduce the serum triglyceride concentration by 30% with associated increase in HDL (Good Cholesterol). This HDL increase reduces the risk of heart diseases. USFDA had given a qualified health claim status to EPA and DHA on coronary heart disease due to the curative effect they provide. The American Heart Association recommends one gram of EPA/DHA per day for patients with coronary heart disease.

Omega-3 fatty acids and cancer: Cancer is one of the most threatening lifestyle diseases having wide spread occurrence irrespective of the generation. Several studies have reported possible anticancer effect of omega-3 fatty acids particularly in breast, colon and prostate cancer. Omega-3 fatty acids were found to reduce the tumour growth as well as slowed histopathological progression. Experimental and epidemiological studies suggested anti-tumour effects of n-3 fatty acids during the initiation and post initiation stages of colon carcinoma. Studies carried out in Sweden showed an inverse association between fatty fish consumption and prostate cancer. Few epidemiological studies assessed on the effect of dietary n-3 fatty acids and breast cancer showed their protective effects against breast cancer risk by inhibiting breast carcinoma development by influencing the biochemical events that follow tumor initiation.

Omega-3 fatty acids and inflammatory diseases: EPA and DHA have anti-inflammatory effect and a role in oxidative stress and to improve cellular function through changes in gene expression. Inflammatory Bowel Disease (IBD) is a general term for chronic inflammatory disease of the GI tract which includes ulcerative colitis and Crohn disease. Crohn's disease can affect the small intestine and large intestine, mouth, oesophagus, stomach and the anus whereas ulcerative colitis primarily affects the colon and the rectum. Studies using animal models provide strong evidence for the protective effects of omega-3 fatty acids against induced IBD. Similarly individuals having lower intake of omega-6/omega3 ratios were 21% less likely to suffer from Crohn disease. Relative studies carried out between population having different fish oil consumption pattern revealed that diet rich in fish oil have an improvement in the number of tender joints when examined physically while some reports revealed improvement in Ritchie Articular Index (measure of joint tenderness) and in morning stiffness .

Omega-3 fatty acids in mental health and neural function:  Human nervous system has the highest lipid content compared to all other tissues excluding adipose tissue. 50-60% of the total dry weight of adult human is lipid and one third being omega-3 PUFAs; mostly DHA. Incorporation of DHA into graving neurons is a prerequisite for synaptogenesis. The Canadian Government has reported that DHA have a biological role supporting the normal development of brain, eyes and nerves. Omega-3 PUFAs are known to have membrane-enhancing capabilities in brain cells which are explained to be due to the major role played by them in fortification of the myelin sheaths and are also found beneficial in repairing brain damage by promoting neuronal growth.

Omega-3 fatty acids for foetal development: Supplementing with EPA and DHA in the diet during pregnancy is associated with multiple benefits for the foetal development. Deficiency of DHA during prenatal development increases probability of diminished visual activity, cerebellar dysfunction, cognitine impairment and neurological disorders. Pregnant and breastfeeding mothers should consume about 8-12 ounce of seafood per week from a variety of seafood source which accounts to nearly 300-900 mg EPA and DHA per day. This is found to be essential for the growth and development of the foetus. Omega-3 supplementation during pregnancy is also associated with longer gestation period and increase in concentration of EPA and DHA in foetal tissue. This is very important as prematurity is the cause of various infant diseases and can even lead to death. Some other reports suggest that mothers using omega-3 fatty acid rich diets during pregnancy and breast feeding may protect their children against allergies which may be due to the fact that fish oil supplementation leads to decreased levels of body cell associated with inflammation and immune responses.

 Omega-3 fatty acids as skin care: Dietary consumption of fish oils rich in omega-3 fatty acids are known to adjust the balance of lipid inflammatory mediators thereby important in the treatment of inflammatory skin disorders. Excessive exposure to UV light is associated with many undesirable skin alterations. Increased exposure to sunlight also increases the chances of nonmelanoma skin cancer. Studies have shown that dietary supplementation with omega-3 PUFAs provides photo protection by being effective against UV-irradiation induced damage. Psoriasis is a common skin disorder characterized by epidermal hyper proliferation and cutaneous inflammation. Severity varies from small localized area to whole body. Researches carried out suggested that an increase in the dietary intake of fish oil and a reduction in the intake of foods rich in arachidonic acid (omega-6 fatty acid) would be beneficial treatment to counteract the exaggerated inflammation in psoriasis.

CONCLUSION: Present life style demands more attention towards health foods on account of the aggravating health problems being generated. The ill effects of chronic diseases like cardiovascular diseases, inflammatory conditions etc can be reduced by regular consumption of seafoods which are rich sources of omega-3 fatty acids like EPA and DHA. Hence more awareness on the importance of this healthy diet needs to be created for the betterment of the society.