Intelligence is one of the most investigated traits in humans and higher intelligence is associated with important economic and health-related life outcomes. Despite high heritability estimates of 45% in childhood and 80% in adulthood, only a handful of genes had previously been associated with intelligence and for most of these genes the findings were not reliable. The study, published in the journal Nature Genetics, uncovered 52 genes for intelligence, of which 40 were completely new discoveries. Most of these genes are predominantly expressed in brain tissue.
The study also showed that the genetic influences on intelligence are highly correlated with genetic influences on educational attainment, and also, albeit less strongly, with smoking cessation, intracranial volume, head circumference in infancy, autism spectrum disorder and height. Inverse genetic correlations were reported with Alzheimer's disease, depressive symptoms, smoking history, schizophrenia, waist-to-hip ratio, body mass index, and waist circumference.
Genetic correlations shed light on common biological pathways for intelligence and other traits. Seven genes for intelligence are also associated with schizophrenia; nine genes also with body mass index, and four genes were also associated with obesity. Future studies will need to clarify the exact role of these genes in intelligence in order to obtain a more complete picture of how genetic differences lead to differences in intelligence. "The current genetic results explain up to 5% of the total variance in intelligence. Although this is quite a large amount of variance for a trait as intelligence, there is still a long road to go: given the high heritability of intelligence, many more genetic effects are expected to be important, and these can only be detected in even larger samples