A new surgical technique devised by MIT researchers could allow prosthetic limbs to feel much more like natural limbs. Through coordination of the patient's prosthetic limb, existing nerves, and muscle grafts, amputees would be able to sense where their limbs are in space and to feel how much force is being applied to them.
This type of system could help to reduce the rejection rate of prosthetic limbs, which is around 20 percent.
In the new study, which appears in Science Robotics on May 31, the researchers demonstrated in rats that their technique generates muscle-tendon sensory feedback to the nervous system, which should be able to convey information about a prosthetic limb's placement and the forces applied to it. They now plan to begin implementing this approach in human amputees, including Herr, whose legs were amputated below the knee when he was 17.
Shriya Srinivasan, a graduate student in the Harvard-MIT Program in Health Sciences and Technology (HST), is the paper's lead author. Other authors are Media Lab visiting scientist Matthew Carty, MIT undergraduate Peter Calvaresi, HST graduate students Tyler Clites and Benjamin Maimon, Media Lab graduate student Cameron Taylor, and recent PhD recipient Anthony Zorzos.
During a conventional limb amputation, muscles are severed in a way that cuts off a key relationship that normally helps people control their limbs and sense where they are in space. Most muscles that control limb movement occur in pairs known as agonist-antagonist pairs, such that one muscle stretches when the other contracts. For example, when you bend your elbow, the biceps muscle contracts, causing the triceps to stretch, and that triceps stretch sends sensory information related to position, velocity, and force back to the brain. The agonist-antagonist muscle relationship is also what allows people to independently control position and stiffness at their limb joints.
Without these intact muscle pairs, persons with limb amputation have no way of sensing where their artificial limbs are, nor can they sense the forces applied to those limbs.
The MIT team set out to recreate these agonist-antagonist muscle relationships. In many amputees, the nerves that send signals to the amputated limb remain intact. The researchers decided to take advantage of those nerves by connecting them to muscle pairs grafted from another part of the body into the amputation site.
These grafts, which would be about 4 centimeters by 1.5 centimeters in humans, consist of a pair of muscles that work together just like natural muscles. When the brain sends signals instructing a limb to move, one of the grafted muscles will contract, and its agonist will extend. The agonist muscle then sends feedback to the brain about how much the muscle moved and the forces applied to it.
In the Science Robotics paper, the researchers tested the muscle grafts in rats and found that when the rats contracted one muscle of the pair, the other muscle would move in the opposite way and send sensory information back to the brain.
In other work, the researchers have developed the components of a control system that will translate the nerve signals into instructions for moving the prosthetic limb. When the brain sends nerve impulses to the regenerated muscles, those signals will also be received by a microprocessor that controls the movement of the artificial limb.
Neural stimulations will cause the agonist muscle to contract and the antagonist muscle to stretch. The stretched muscle will then provide neural feedback to allow the patient to feel where his or her limb is in space. The researchers expect that the brain will be able to rapidly learn how much control it has to exert to make an artificial limb move in the desired way.